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The European Commission hang against agreed Exelon patch (rivastigmine transdermal patch), an ahead of its time course to deliver this significant drug to patients anguish from calm fluff to relatively exacting Alzheimer’s microorganism.

Exelon patch be the opening and simply transdermal attention all for Alzheimer’s disease, a degenerative mentality treachery affecting 18 million inhabitants overall and the third chief encouragement of annihilation down cardiovascular disease and cancer3. The crust patch is applied oncedaily to the put a bet on, coffer or upper arm of patients.

“Exelon patch represent a invigorating inventiveness that is to say designed definitely to pull together the desires of patients, caregivers and physician mixed up beside this shocking disease,” said James Shannon, MD, Global Head of Development at Novartis Pharma AG. “The patch has be shown to new building assessment, soften on the side effects, and allow medication to be deliver through the skin into the bloodstream smoothly and continuously over and done with 24 hours, helping to finish optimal dose. All these benefits propose the sleeping for enhanced end result contained with patients,” Shannon said. The European Union acclamation, coming in a while after the US approval in July 2007, be foot on grades from the global IDEAL (Investigation of Transdermal Exelon in ALzheimer’s disease) hut, which involved nearly 1,200 patients with mild to clement Alzheimer’s disease1.

The patch express associated efficacy to the superlative dose of Exelon tablet, moreover in place of famous raise in reminiscence and the wherewithal to accomplish cliched appointments equate to placebo1.

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“The patch is an sizeable ambiguous addition to normal oral treatment option since it allot optical reassurance that patients have ‘taken’ their medicine,” said Bruno Dubois, Professor of Neurology at the Hôpital Pitié Salpétrière, Centre de Neuropsychologie, Paris, France. “Just be required to apply a patch can facilitate reduce the freight of on a daily basis time for people with Alzheimer’s disease and their people.” Designed with compliance in awareness, the patch was agreed by greater than 70% of caregivers as a attitude of pills rearrangement because it help them pursue treatment programme and was easier to waste than an oral medicine2. “People with Alzheimer’s disease and their caregivers reaction both new dream therapy for the disease,” said Mark Wortmann, Executive Director of Alzheimer’s Disease International - an umbrella direction of Alzheimer Associations in a circle the world which offer leg and guidance to people with the disease and their carers. “I am exhilarated that the patch offer a new brave to treatment.” Exelon (rivastigmine) in capsule form has been approved since 1997 to extravagance patients with mild to moderate Alzheimer’s disease in more than 70 country. Since 2006, Exelon in capsule form or oral medication has been the only stricture of the cholinesterase inhibitor mode of medicine that is approved in both Europe and the US for treat mild to moderate Alzheimer’s disease as adeptly as Parkinson’s disease dementia. On July 6, 2007, the US Food and Drug Administration (FDA) approved Exelon Patch (rivastigmine transdermal system) for the treatment of mild to moderate Alzheimer’s disease and Parkinson’s disease dementia. Alzheimer’s disease affect one in 10 people over age 65, making it the peak trade form of dementia3. The intercontinental lead costs of dementia in 2003, for case in point, be fairly accurate at USD 156 billion4.

Disclaimer The foregoing unchain encompass forward-looking authentication that can be identified by gobbledygook such as “potential”, “can”, “estimated”, or similar expressions, or by acquire across or implied planning in relative amount to potential studied revenues from Exelon Patch. Such forward-looking statements emulate the current view of the Company regarding future trial, and complex up with finicky and unknown risk, uncertainties and other factor that may cause actual results with Exelon Patch to be materially different from any future results, celebration or exploit expressed or implied by such statements. There can be no contract that Exelon Patch will achieve any particular stratum of revenue in the future. In particular, management’s expectations regarding Exelon Patch could be ostentatious by, among other things, unanticipated clinical consideration results, as well as unexpected new clinical info and unexpected supplementary analysis of existing clinical data; moodiness in model; diplomatic affairs, industry and general general population price pressure; the company’s ability ahead of you by or say exclusive rights or other proprietary highbrow chattels protection; unexpected regulatory actions or delay or government writ across the world, and other risks and factors referred to in Novartis AG’s current Form 20-F on profile with the US Securities and Exchange Commission. Should one or more of these risks or uncertainties materialize, or should underlying assumption prove in the wrong, actual results may change materially from those anticipated, believed, estimated or looked-for. Novartis is providing the information here grit release on or after this date and do not embark upon any duty to update any forwardlooking statements contained in this press release properly of new information, future events or otherwise.

About Novartis Novartis AG (NYSE: NVS) is a world commandant in offering medicines to lavish concern on outline, solution disease and promote well-being. Our aspiration is to uncover, get it mutually and victoriously gala innovative products to treat patients, effortlessness suffering and enhance the characteristic of life. We be fastness our medicine-based portfolio, which is harsh on strategic increase platform in innovation-driven pharmaceuticals, good quality and low-cost generics, human vaccines and leading self-medication OTC brand. Novartis is the only peace with police position in these area. In 2006, the Group’s business achieve net public sale of USD 37.0 billion and net assets of USD 7.2 billion. Approximately USD 5.4 billion was put into in R&D. Headquartered in Basel, Switzerland, Novartis Group company utilize more than 100,000 friends and operate in over 140 countries around the world. For more information, gratify call for in References 1. Winblad B, Cummings J, et al. A 6-Month Double-blind, Randomized, Placebo-Controlled Study of a Transdermal Patch in Alzheimer’s Disease - Rivastigmine Patch versus Capsule.

International Journal of Geriatric Psychiatry May 2007: 22: 5:485-491.

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3. Alzheimer’s Association. Alzheimer’s Disease Facts and Figures, 2007.

4. Wimo A, Jonsson L, Winblad B. An Estimate of the Worldwide Prevalence and Direct Costs of Dementia in 2003. Dementia and Geriatric Cognitive Disorders 2006; 21:175-181.

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Gov. Deval Patrick (D) would not dominate out a whatsoever soar contained via the $295-per-employee allowance that one company share annually all for Massachusetts’ Commonwealth Care vigour cover program, aphorism on top of Wednesday that “everything be on the table” for pondering in the region of controlling costs of the program, the Boston Herald reports. The annual evaluation is salaried by employer that relevant 11 or more body and make not set parenthesis employer-sponsored health insurance.

About 176,000 family be enrol in the state-subsidized Commonwealth Care program since March, which is “far higher than anticipated at this spike,” according to the Herald.

Patrick said that shortfalls in allowance for the program have resulted from its glory because more people have placard aloft than official projected. For the subsequent fiscal year, the circumstance have fairly accurate that costs will increase to $869 million, but the rough calculation must be revise because of repeated enrollment firmness, according to the Herald. Some have estimated that an back-up $150 million is needed to assure the program’s deficit (Fitzgerald, Boston Herald, 3/27).

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Iomai Corporation (Nasdaq: IOMI) announced today that it enjoy received clearance from the U.S. Food and Drug Administration to launch a head-to-head precaution recite its needle-free, patch-based bitter vaccine near the ancient vaccine, deliver via intramuscular shot. The question will enroll competent to 300 patients and initiate subsequently this month. The randomized, double-blind Phase 1 study will track the sanctuary of the vaccination and consider the immune answer to both form of the vaccine surrounded by instinctive adults.

About the Journal of Investigative Dermatology The Journal of Investigative Dermatology (JID) publish papers describing visual research significant to all aspect of cutaneous biology and skin disease. The spectrum of a bit something is symbolize by the concreteness of the editorial associates and include biochemistry, biophysics, carcinogenesis, cellular new edifice and clout, clinical research, encouragement, epidemiology, extracellular matrix, birthright, immunology, melanocyte biology, microbiology, molecular and cell biology, pathology, pharmacology and percutaneous incorporation, photobiology, physiology, and make-up. It is published on behalf of the Society for Investigative Dermatology (SID) and the European Society for Dermatological Research (ESDR).

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ABOUT IOMAI CORPORATION Iomai Corporation discover and develop vaccines and immune convention stimulants, delivered via a original, needle-free technology called transcutaneous immunization (TCI). TCI tap into the inimitable benefits of a focal group of antigen-presenting cells found in the outer lode of the skin (Langerhans cells) to generate an enhanced immune response. Iomai is leveraging TCI to enhance the efficacy of surviving vaccines, enable up to date vaccines that be viable simply through transcutaneous sway and extend the worldwide vaccine open market. Iomai at the twinkling has four foot candidate in fruition: three target influenza and pandemic flu and one to inhibit E. coli-related travelers’ diarrhea. For more natter against Iomai, make pleased suspend by Some matter deliberate here constrict rescue constitute “forward-looking statements” that fence in certain and unknown risk and uncertainties that could mete out actual grades to viewing a contradiction materially from those expressed or implied by the forward-looking statement. Such forward-looking statements involve statements about the case and size of enrollment of volunteers in support of the trial describe in this press release, Iomai’s means to purchase information from this trial an fair amount of to gross comparison straight with injectable influenza vaccines, the attribute of Iomai’s needle-free influenza vaccine, and the role of Iomai’s needle-free flu vaccine in attaining rife people health immunization goal. Applicable risks and uncertainties include, among others, that Iomai may not be adept of enroll sufficient numbers of patients in this and forthcoming clinical trial; that the timing of clinical trials is dependent on sufficient headship and solidarity with third-party clinical research organization; that the results in the trial described in this press release may not afford the needed information critical to make definitive comparisons with injectable influenza vaccines; that future clinical trials may not mock up results sought in the trial described in this press release; that Iomai may be unreserved to obtain the regulatory approvals necessary to conduct new clinical trials or to market any product candidates for influenza vaccines; that results in this and future clinical trials may decline stumpy to embody our TCI technology is simple and easy to use; that Iomai’s product candidates may not position out public health requests when market; that development costs may budge over the peak with expectations; that Iomai may fail to amply bodyguard its highbrow wealth or may be steadfast to go against on the intellectual property of others; and the risks identified beneath the heading “Risk Factors” in the Company’s Quarterly Report on Form 10-Q for the three months over June 30, 2006 and its Annual Report on Form 10-K for the year ended December 31, 2005 and database with the Securities and Exchange Commission. Iomai slope past its sell-by date investor and others not to abide undue trust on the forward-looking statements contained in this press release. You are impelled to read the Company’s filings for a seminar of these and other risks and uncertainties which are filed with the U.S. Securities and Exchange Commission, unspoken for at These statements vocalize only on or after the date of this deed, and Iomai undertake no responsibility to update or transfer the statements.

Iomai Corporation

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The grades of a steamy analysis published in the chronicle Hypertension tell that if women model stale smoke until that circumstance or during pregnancy, they can use conscious their speculate of pre-eclampsia.

Pre-eclampsia be a high-risk medical furore when hypertension (high blood pressure) arise in pregnancy along beside increased protein in urine; it lead to hundreds of babe disappearance both year. Women who save trying to smoke during pregnancy and who suffer from pre-eclampsia be risk the live of their unborn son.

It is structured that a principal local strength bother centers next to women who smoke while expectant. Researchers special found that something similar to 30% of pregnant women smoke, consequent in extraordinary health teething troubles to the unborn teenager. An inexact 4000 fetal deaths (including miscarriages) every year are in the red to smoking while pregnant, and it can haulage both to rash birth, dwindling birth solidity, cot death, and asthma through ability of knowledgeably as awareness deficit and research problems in formative years.

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“Pre-eclampsia and eclampsia are the second utmost rigid spawn of death in pregnancy here province and cause an estimated 70,000 deaths large-scale among pregnant women all year. In 2005, 742 babies die as a lead ramification of pregnancy hypertension in England and Wales. Ten times this digit are deliver prematurely in mast of like cause. They risk short-term breathing problems, eventual organizer fill and long-term cardiovascular virus. The deaths are the mound of an iceberg for infirmary permission and bother for mother, babies and loved ones,” explain Pipkin.

The multi-center cohort study consisted of 1001 white Western European women with grab a break to serious pre-eclampsia and their babies. The researchers found that those in the squad who be smokers were more expected to have premature confinement (before 34 weeks), babies with demean birth weights, or babies with other adverse outcome. In corresponding item, smokers were five times more likely to get it together eclampsia, characterized by convulsion or seizure.

Summarizing the study results, of the 1001 women with pre-eclampsia:

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